Stephan Scheeff
Stephan Scheeff

Post-Doctoral Researcher in Antiviral Drug Design

Chinese University of Hong Kong

About Me

My name is Stephan Scheeff, and I am a chemist working on the design and synthesis of antiviral compounds. Since 2021, I have been engaged in research on nucleoside analogues as part of the research group led by Prof. Billy Ng at the Chinese University of Hong Kong. For this work I was awarded with the Hong Kong Postdoctoral Fellowship 2022/2023.

Aside from conducting research, I enjoy exploring the countryside and culture in Hong Kong and follow my passion for photography.

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Interests
  • Drug Discovery
  • Antiviral Drugs
  • Total Synthesis
Education

  • Total Synthesis of Natural Products - Dr. rer. nat. (equivalent to PhD)

    University of Bonn

  • Organic Chemistry - Diplom in Chemistry

    Humboldt University of Berlin

Experience

  1. Post-Doctoral Fellow

    Chinese University of Hong Kong
    Design and synthesis of novel nucleoside analogs for antiviral purposes together with Prof Billy Ng (School of Pharmacy).

  2. Post-Doctoral Fellow

    University of Hong Kong
    Development of synthetic novel methods in the field of reductive copper catalyzed transformations in the research group of Prof Pauline Chiu (Department of Chemistry).

  3. Research Assistant

    Dresden University of Technology
    Total synthesis of natural products together with Prof Peter Metz (Department of Chemistry).

Education

  1. Total Synthesis of Natural Products - Dr. rer. nat. (equivalent to PhD)

    University of Bonn
    During my time at the University of Bonn, I participated in the research group of Professor Dirk Menche, where I contributed to the total synthesis of polyketide natural products.
    Read Thesis (in german)

  2. Organic Chemistry - Diplom in Chemistry

    Humboldt University of Berlin
    I completed a 5-year study program at the Humboldt University in Berlin. For my thesis, I conducted research in the group of Professor Rainer Mahrwald, focusing on organocatalytic Aldol condensations.
Awards
Hong Kong Post Doctoral Fellowship 2022/2023
Hong Kong University Grants Comittee ∙ April 2023
Featured Publications
Diastereo- and Enantioselective Construction of Stereochemical Arrays Exploiting Non-Classical Hydrogen Bonding in Enolborates
Design and Synthesis of Bicyclo [4.3.0] nonene Nucleoside Analogues
Total synthesis of archazolid F
Skills & Hobbies
Science
Research & Labwork
Grant Writing
Mentoring
Hobbies
Hiking
Photography
Recent Publications
Xiaoding Jiang, Xu He, Jonathan Wong, Stephan Scheeff, Sam Chun Kit Hau, Tak Hin Wong, Yao Qin, Chi Hang Fan, Bowen Ma, Ngai Lam Chung, Junzhe Huang, Jiajia Zhao, Yu Yan, Min Xiao, Xueqin Song, Tony K. C. Hui, Zhong Zuo, William Ka-Kei Wu, Ho Ko, Kim Hei-Man Chow, Billy Wai-Lung Ng (2024). Lactone-to-Lactam Editing Alters the Pharmacology of Bilobalide. JACS Au 2024.
DOI Link to full-text
Matthew Tin-Lok Li, Stephan Scheeff, Jiahua Chen, Ryne C. Johnston, Antonio Rizzo, Elizabeth H. Krenske, Pauline Chiu (2024). Diastereo- and Enantioselective Construction of Stereochemical Arrays Exploiting Non-Classical Hydrogen Bonding in Enolborates. Chem. Eur. J. 2024, e202401485.
Cite DOI Link to full-text
Stephan Scheeff, Yan Wang, Mao-Yun Lyu, Behzad Nasiri Ahmadabadi, Sam Chun Kit Hau, Tony KC Hui, Yufeng Zhang, Zhong Zuo, Renee Wan Yi Chan, Billy Wai-Lung Ng (2023). Design and Synthesis of Bicyclo [4.3.0] nonene Nucleoside Analogues. Org. Lett. 2023, 25, 50, 9002–9007.
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Billy Wai-Lung Ng, Stephan Scheeff, Josefina Xeque Amada (2023). Making it hard to replicate. Elife https://doi.org/10.7554/eLife.88044.
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Siyuan Guo, Kong Ching Wong, Stephan Scheeff, Zhuo He, Wesley Ting Kwok Chan, Kam-Hung Low, Pauline Chiu (2022). Copper-Catalyzed Reductive Ireland - Claisen Rearrangements of Propargylic Acrylates and Allylic Allenoates. J. Org. Chem. 2022, 87, 1, 429–452.
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Languages
100%
German
100%
English
70%
Cantonese
40%
French