Efficient Synthesis of Chiral ProTides through Copper Catalysis
A new study introduces a novel method for the stereoselective synthesis of chiral phosphates in ProTide nucleoside analogues.
Nov 13, 2024
Exploring Anti-Bredt Olefins as Reactive Intermediates
The access and the usage of anti-Bredt type olefins as intermediates are described in a new study in Science.
Nov 10, 2024
A Day in Nature: Hiking Ma On Shan Country Park
Going for a hike from Shatin to Ma On Shan, I discovered breathtaking views of Sai Kung in the heart of Ma On Shan Country Park.
Oct 13, 2024
Start of the 2024/2025 Hiking Season: Scenic views from Lion Rock
Finally, the weather cooled down, allowing me to climb Lion Rock, which connects Shatin and Kowloon.
Oct 5, 2024
Personal Review: International Symposium on Medicinal Chemistry
Synthesis of stasseriolide natural products and their analogues using a ring-closing alkyne metathesis by Alois Fürstner and his team.
Sep 10, 2024
Macrocycles can lock the Conformation of Drug Candidates and enhance their Activity
Macrocycles can improve the conformation, biological activity, selectivity, ADME properties, and target affinity of small-molecule drug candidates.
Sep 10, 2024
Synthesis of Quaternary Centres using Lithium Enolates in a Ru-catalysed Allylic substitution
The construction of quaternary centers via C-C bond formation is a significant challenge, but a new method reported in JACS, provides a promising approach to accessing these sterically crowded motifs.
Aug 24, 2024
Synthesis of Drug Libraries using Sulfamide Linker Strategy
A coupling strategy ready for use in a 96 well plate.
Aug 21, 2024
Ring Closing Alkyne Metathesis allows unified Synthesis of Strasseriolides A to D
Synthesis of stasseriolide natural products and their analogues using a ring-closing alkyne metathesis by Alois Fürstner and his team.
Aug 10, 2024
Pfizer's Second-Generation SARS-CoV-2 Protease Inhibitor
Researchers from Pfizer have developed a structurally-optimized SARS-CoV-2 main protease inhibitor with improved metabolic stability compared to nirmatrelvir which is now in clinical trials.
Jul 27, 2024