Pfizer's Second-Generation SARS-CoV-2 Protease Inhibitor
Researchers from Pfizer have developed a structurally-optimized SARS-CoV-2 main protease inhibitor with improved metabolic stability compared to nirmatrelvir which is now in clinical trials.
Jul 27, 2024
Biocatalytic diversification of thionucleoside analogues
Novel biocatalytic method for the diversification of thionucleosides, demonstrating that enzyme-catalyzed transglycosylation can effectively facilitate nucleobase exchange.
Jul 23, 2024
Learning Cantonese: Should I learn the Chinese Characters?
Why the learning of Chinese characters is important and what the benefits are.
Jul 21, 2024
![Breaking the aromaticity of thiophene using a [4+3] cycloaddition](/post/thiophene-angew-2024/featured_hu1805644071449431251.webp)
Breaking the aromaticity of thiophene using a [4+3] cycloaddition
A novel dearomative, intramolecular [4+3]-cycloaddition of thiophenes at low temperatures yielding complex tricyclic ring systems.
Jul 19, 2024
Novel remdesivir type nucleoside analogue displays broad-spectrum antiviral activity
The development of a novel 4'-CN remdesivir-type nucleoside analogue demonstrating the potential of 4-aza-7,9-dideazaadenosine nucleoside analogues to exhibit antiviral activity.
Jul 15, 2024
Structural Modifications Enhance Antibacterial Potency of Bacitracin
Researchers modified the structure of the established antibiotic bacitracin, leading to a 256-fold increase in activity and potent inhibition of vancomycin-resistant strains.
Jul 13, 2024
Novel Synthesis Route to Platensilin and Analogues
Researchers from Shandong University in China reported the total synthesis of platensilin and platensimycin, as well as the formal synthesis of platencin in JACS, using a biomimetic approach that allowed the formation of all three natural products from a common precursor.
Jul 9, 2024
Exploring Xiamen on a Short trip
Xiamen is a coastal city in southeastern China's Fujian province. I enjoyed its cultural heritage, beautiful natural landscapes and relaxed atmosphere during my short trip.
Jul 2, 2024
My Reading Tip of the Week: Total Synthesis of Scabrolide A by Radical Cascade
A radical cascade strategy to synthesize the complex marine natural product, Scabrolide A, is described in JACS by Pengfei Hu and coworkers.
Jun 1, 2024
Hiking in Tsing Yi
As the weather in Hong Kong becomes increasingly humid in late spring, hiking can become more challenging, but the island of Tsing Yi offers rewarding hiking options well-suited for the conditions, including the scenic Sam Chi Heung peaks.
May 29, 2024