Personal Review: International Symposium on Medicinal Chemistry
Synthesis of stasseriolide natural products and their analogues using a ring-closing alkyne metathesis by Alois Fürstner and his team.
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3 min read
Macrocycles can lock the Conformation of Drug Candidates and enhance their Activity
Macrocycles can improve the conformation, biological activity, selectivity, ADME properties, and target affinity of small-molecule drug candidates.
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1 min read
Synthesis of Quaternary Centres using Lithium Enolates in a Ru-catalysed Allylic substitution
The construction of quaternary centers via C-C bond formation is a significant challenge, but a new method reported in JACS, provides a promising approach to accessing these …
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1 min read
Synthesis of Drug Libraries using Sulfamide Linker Strategy
A coupling strategy ready for use in a 96 well plate.
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1 min read
Ring Closing Alkyne Metathesis allows unified Synthesis of Strasseriolides A to D
Synthesis of stasseriolide natural products and their analogues using a ring-closing alkyne metathesis by Alois Fürstner and his team.
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1 min read
Pfizer's Second-Generation SARS-CoV-2 Protease Inhibitor
Researchers from Pfizer have developed a structurally-optimized SARS-CoV-2 main protease inhibitor with improved metabolic stability compared to nirmatrelvir which is now in …
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1 min read
Biocatalytic diversification of thionucleoside analogues
Novel biocatalytic method for the diversification of thionucleosides, demonstrating that enzyme-catalyzed transglycosylation can effectively facilitate nucleobase exchange.
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1 min read
Learning Cantonese: Should I learn the Chinese Characters?
Why the learning of Chinese characters is important and what the benefits are.
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4 min read
![Breaking the aromaticity of thiophene using a [4+3] cycloaddition featured image](/post/thiophene-angew-2024/featured_hu_950411bbaf1d50d7.webp)
Breaking the aromaticity of thiophene using a [4+3] cycloaddition
A novel dearomative, intramolecular [4+3]-cycloaddition of thiophenes at low temperatures yielding complex tricyclic ring systems.
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1 min read
Novel remdesivir type nucleoside analogue displays broad-spectrum antiviral activity
The development of a novel 4'-CN remdesivir-type nucleoside analogue demonstrating the potential of 4-aza-7,9-dideazaadenosine nucleoside analogues to exhibit antiviral activity.
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1 min read