A novel dearomative, intramolecular [4+3]-cycloaddition of thiophenes at low temperatures yielding complex tricyclic ring systems.
Jul 19, 2024
The development of a novel 4'-CN remdesivir-type nucleoside analogue demonstrating the potential of 4-aza-7,9-dideazaadenosine nucleoside analogues to exhibit antiviral activity.
Jul 15, 2024
Researchers modified the structure of the established antibiotic bacitracin, leading to a 256-fold increase in activity and potent inhibition of vancomycin-resistant strains.
Jul 13, 2024
Researchers from Shandong University in China reported the total synthesis of platensilin and platensimycin, as well as the formal synthesis of platencin in JACS, using a biomimetic approach that allowed the formation of all three natural products from a common precursor.
Jul 9, 2024
Xiamen is a coastal city in southeastern China's Fujian province. I enjoyed its cultural heritage, beautiful natural landscapes and relaxed atmosphere during my short trip.
Jul 2, 2024
A radical cascade strategy to synthesize the complex marine natural product, Scabrolide A, is described in JACS by Pengfei Hu and coworkers.
Jun 1, 2024
As the weather in Hong Kong becomes increasingly humid in late spring, hiking can become more challenging, but the island of Tsing Yi offers rewarding hiking options well-suited for the conditions, including the scenic Sam Chi Heung peaks.
May 29, 2024
The efficacy of triphosphate formation of remdesivir is dependent on ProTide substitution. Higher levels of triphosphate in the lung are observed with ProTide prodrugs.
May 24, 2024