Total synthesis of archazolid F
January 4, 2019·
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0 min read
Stephan Scheeff
Dirk Menche
Abstract
A partial bioinspired as well as the total synthesis of archazolid F, a highly potent V-ATPase inhibitory, antiproliferative polyketide macrolide, is described. Key features of the synthetic routes include a highly stereoselective aldol condensation of two elaborate fragments and macrocyclizations either by a Shiina macrolactonization or by a challenging RCM reaction of an octaene substrate. The syntheses unequivocally confirm the full architecture of this very scarce archazolid.
Type
Publication
Org. Lett. 2019, 21, 1, 271–274.
Authors
Research Associate (Medicinal Chemistry)
Medicinal chemist designing novel antiviral and anticancer compounds. Researched nucleoside analogues at CUHK under Prof. Billy Ng since 2021, awarded Hong Kong Postdoctoral Fellowship 2022/2023. Enjoys exploring Hong Kong’s countryside and culture through photography.