Design and synthesis of bicyclo[4.3.0]nonene nucleoside analogues
December 22, 2023·
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Stephan Scheeff
contributed equally
,Yan Wang
contributed equally
,Mao-Yun Lyu
Behzad Nasiri Ahmadabadi
Sam Chun Kit Hau
Tony K C Hui
Yufeng Zhang
Zhong Zuo
Renee Wan Yi Chan
Billy Wai-Lung Ng
Abstract
Nucleoside analogues are effective antiviral agents, and the continuous emergence of pathogenic viruses demands the development of novel and structurally diverse analogues. Here, we present the design and synthesis of novel nucleoside analogues with a carbobicyclic core, which mimics the conformation of natural ribonucleosides. Employing a divergent synthetic route featuring an intermolecular Diels-Alder reaction, we successfully synthesized carbobicyclic nucleoside analogues with high antiviral efficacy against respiratory syncytial virus.
Type
Publication
Org. Lett. 2023, 25, 50, 9002–9007
Authors
Research Associate (Medicinal Chemistry)
Medicinal chemist designing novel antiviral and anticancer compounds. Researched nucleoside analogues at CUHK under Prof. Billy Ng since 2021, awarded Hong Kong Postdoctoral Fellowship 2022/2023. Enjoys exploring Hong Kong’s countryside and culture through photography.