Novel Nucleoside Analogues to Combat Emerging Diseases
Viral diseases are an ever-present threat to public health, a reality the COVID-19 pandemic made painfully clear. While effective antiviral treatments exist for chronic diseases …
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3 min read
Antiviral profiling and cellular activation of carbobicyclic nucleoside analogues
Nucleoside analogues are important antiviral and anticancer agents. In this study, we investigated a new class of nucleoside analogues built on a synthetically accessible …
Pfizer's Second-Generation SARS-CoV-2 Protease Inhibitor
Researchers from Pfizer have developed a structurally-optimized SARS-CoV-2 main protease inhibitor with improved metabolic stability compared to nirmatrelvir which is now in …
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1 min read
Novel remdesivir type nucleoside analogue displays broad-spectrum antiviral activity
The development of a novel 4'-CN remdesivir-type nucleoside analogue demonstrating the potential of 4-aza-7,9-dideazaadenosine nucleoside analogues to exhibit antiviral activity.
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1 min read
My Reading Tip of the Week: Efficacy of Remdesivir ProDrugs
The efficacy of triphosphate formation of remdesivir is dependent on ProTide substitution. Higher levels of triphosphate in the lung are observed with ProTide prodrugs.
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1 min read
![Design and synthesis of bicyclo[4.3.0]nonene nucleoside analogues featured image](/publications/scheeff-2023-hj/featured_hu_b923ed2bcb2d56c8.webp)
Design and synthesis of bicyclo[4.3.0]nonene nucleoside analogues
Nucleoside analogues are effective antiviral agents, and the continuous emergence of pathogenic viruses demands the development of novel and structurally diverse analogues. Here, …
Making it hard to replicate
Understanding how to harden liquid condensates produced by influenza A virus could accelerate the development of novel antiviral drugs.
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