Efficient Synthesis of Chiral ProTides through Copper Catalysis
A new study introduces a novel method for the stereoselective synthesis of chiral phosphates in ProTide nucleoside analogues.
Nov 13, 2024
Synthesis of Quaternary Centres using Lithium Enolates in a Ru-catalysed Allylic substitution
The construction of quaternary centers via C-C bond formation is a significant challenge, but a new method reported in JACS, provides a promising approach to accessing these sterically crowded motifs.
Aug 24, 2024
My Reading Tip of the Week: Total Synthesis of Scabrolide A by Radical Cascade
A radical cascade strategy to synthesize the complex marine natural product, Scabrolide A, is described in JACS by Pengfei Hu and coworkers.
Jun 1, 2024