Molecular Editing

Molecular editing of bilobalide: Regioselective C-ring lactam formation featured image

Molecular editing of bilobalide: Regioselective C-ring lactam formation

Late-stage diversification of complex natural products enables rapid access to analogues for structure-activity relationship studies. Herein, we report a regioselective …

wenjing-wang

Lactone-to-lactam editing alters the pharmacology of bilobalide

Precise transformations of natural products (NPs) can fine-tune their physicochemical properties while preserving inherently complex and evolutionarily optimized parent scaffolds. …

xiaoding-jiang
Molecular Editing of Natural Products featured image

Molecular Editing of Natural Products

Natural products serve as powerful templates for drug development. The biosynthesis of secondary metabolites demands significant energy from the organism, which suggests that these …