Natural products offer privileged three-dimensional chemotypes for drug discovery, yet scaffold lability and limited analogue space often impede mechanism-guided optimization. …
Late-stage diversification of complex natural products enables rapid access to analogues for structure-activity relationship studies. Herein, we report a regioselective …
Precise transformations of natural products (NPs) can fine-tune their physicochemical properties while preserving inherently complex and evolutionarily optimized parent scaffolds. …
Natural products serve as powerful templates for drug development. The biosynthesis of secondary metabolites demands significant energy from the organism, which suggests that these …