Molecular Editing

Molecular editing of bilobalide: Regioselective C-ring lactam formation

Late-stage diversification of complex natural products enables rapid access to analogues for structure-activity relationship studies. Herein, we report a regioselective …

wenjing-wang

Lactone-to-lactam editing alters the pharmacology of bilobalide

Precise transformations of natural products (NPs) can fine-tune their physicochemical properties while preserving inherently complex and evolutionarily optimized parent scaffolds. …

xiaoding-jiang