Total Synthesis of Complex Natural Products
Total synthesis stands as one of the most intellectually demanding and logistically challenging disciplines within organic chemistry. Unlike highly applied branches such as process …
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4 min read
Molecular editing of bilobalide: Regioselective C-ring lactam formation
Late-stage diversification of complex natural products enables rapid access to analogues for structure-activity relationship studies. Herein, we report a regioselective …
wenjing-wang
Lactone-to-lactam editing alters the pharmacology of bilobalide
Precise transformations of natural products (NPs) can fine-tune their physicochemical properties while preserving inherently complex and evolutionarily optimized parent scaffolds. …
xiaoding-jiang
Molecular Editing of Natural Products
Natural products serve as powerful templates for drug development. The biosynthesis of secondary metabolites demands significant energy from the organism, which suggests that these …
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2 min read
Modular total synthesis of iso-archazolids and archazologs
Full details on the design, development, and successful implementation of suitable synthetic strategies directed toward the total synthesis of iso-archazolids and archazologs are …
Synthesis of novel potent archazolids: Pharmacology of an emerging class of anticancer drugs
Vacuolar type ATPase (V-ATPase) has recently emerged as a promising novel anticancer target based on extensive in vitro and in vivo studies with archazolids, complex polyketide …
Total synthesis of archazolid F
A partial bioinspired as well as the total synthesis of archazolid F, a highly potent V-ATPase inhibitory, antiproliferative polyketide macrolide, is described. Key features of the …
Total syntheses of the archazolids: an emerging class of novel anticancer drugs
V-ATPase has recently emerged as a promising novel anticancer target based on extensive in vitro and in vivo studies with the archazolids, complex polyketide macrolides which …
Modular synthesis of the pyrimidine core of the manzacidins by divergent Tsuji-Trost coupling
The design, development and application of an efficient procedure for the concise synthesis of the 1,3-syn- and anti-tetrahydropyrimidine cores of manzacidins are reported. The …
sebastian-bretzke