Nucleoside Analogues

Efficient Synthesis of Chiral ProTides through Copper Catalysis featured image

Efficient Synthesis of Chiral ProTides through Copper Catalysis

A new study introduces a novel method for the stereoselective synthesis of chiral phosphates in ProTide nucleoside analogues.

Biocatalytic diversification of thionucleoside analogues featured image

Biocatalytic diversification of thionucleoside analogues

Novel biocatalytic method for the diversification of thionucleosides, demonstrating that enzyme-catalyzed transglycosylation can effectively facilitate nucleobase exchange.