Total Synthesis of Complex Natural Products
Total synthesis stands as one of the most intellectually demanding and logistically challenging disciplines within organic chemistry. Unlike highly applied branches such as process …
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4 min read
Molecular editing of bilobalide: Regioselective C-ring lactam formation
Late-stage diversification of complex natural products enables rapid access to analogues for structure-activity relationship studies. Herein, we report a regioselective …
wenjing-wang
Antiviral profiling and cellular activation of carbobicyclic nucleoside analogues
Nucleoside analogues are important antiviral and anticancer agents. In this study, we investigated a new class of nucleoside analogues built on a synthetically accessible …
Deracemisation lead to enriched alpha Amino Aldehydes
Luo and coworkes from Tsinghua University report a novel method for deracemisation in JACS
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1 min read
Practical access to trisubstituted Morita‐Baylis‐Hillman‐type products through copper‐catalyzed reductive aldol reactions of alkynones
AbstractWe report a convenient and diastereoselective copper‐catalyzed reductive alkynone aldol addition to aldehydes, with pinacolborane as stoichiometric reductant, that results …
Lactone-to-lactam editing alters the pharmacology of bilobalide
Precise transformations of natural products (NPs) can fine-tune their physicochemical properties while preserving inherently complex and evolutionarily optimized parent scaffolds. …
xiaoding-jiang
Diastereo- and enantioselective construction of stereochemical arrays exploiting non-classical hydrogen bonding in enolborates
We report a copper-catalyzed reductive aldol addition to aldehydes and ketones, with pinacolborane as stoichiometric reductant, that results in the generation of stereodefined …
matthew-li
![Breaking the aromaticity of thiophene using a [4+3] cycloaddition featured image](/post/thiophene-angew-2024/featured_hu_950411bbaf1d50d7.webp)
Breaking the aromaticity of thiophene using a [4+3] cycloaddition
A novel dearomative, intramolecular [4+3]-cycloaddition of thiophenes at low temperatures yielding complex tricyclic ring systems.
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1 min read
![Design and synthesis of bicyclo[4.3.0]nonene nucleoside analogues featured image](/publications/scheeff-2023-hj/featured_hu_b923ed2bcb2d56c8.webp)
Design and synthesis of bicyclo[4.3.0]nonene nucleoside analogues
Nucleoside analogues are effective antiviral agents, and the continuous emergence of pathogenic viruses demands the development of novel and structurally diverse analogues. Here, …
Copper-catalyzed reductive Ireland-Claisen rearrangements of propargylic acrylates and allylic allenoates
The copper-catalyzed reductive Ireland-Claisen rearrangement of propargylic acrylates led to 3,4-allenoic acids. The use of silanes or pinacolborane as stoichiometric reducing …
siyuan-guo