![Design and synthesis of bicyclo[4.3.0]nonene nucleoside analogues featured image](/publications/scheeff-2023-hj/featured_hu_b923ed2bcb2d56c8.webp)
Design and synthesis of bicyclo[4.3.0]nonene nucleoside analogues
Nucleoside analogues are effective antiviral agents, and the continuous emergence of pathogenic viruses demands the development of novel and structurally diverse analogues. Here, …
Copper-catalyzed reductive Ireland-Claisen rearrangements of propargylic acrylates and allylic allenoates
The copper-catalyzed reductive Ireland-Claisen rearrangement of propargylic acrylates led to 3,4-allenoic acids. The use of silanes or pinacolborane as stoichiometric reducing …
siyuan-guo
Modular total synthesis of iso-archazolids and archazologs
Full details on the design, development, and successful implementation of suitable synthetic strategies directed toward the total synthesis of iso-archazolids and archazologs are …
Synthesis of novel potent archazolids: Pharmacology of an emerging class of anticancer drugs
Vacuolar type ATPase (V-ATPase) has recently emerged as a promising novel anticancer target based on extensive in vitro and in vivo studies with archazolids, complex polyketide …
Total synthesis of archazolid F
A partial bioinspired as well as the total synthesis of archazolid F, a highly potent V-ATPase inhibitory, antiproliferative polyketide macrolide, is described. Key features of the …
Total syntheses of the archazolids: an emerging class of novel anticancer drugs
V-ATPase has recently emerged as a promising novel anticancer target based on extensive in vitro and in vivo studies with the archazolids, complex polyketide macrolides which …
Modular synthesis of the pyrimidine core of the manzacidins by divergent Tsuji-Trost coupling
The design, development and application of an efficient procedure for the concise synthesis of the 1,3-syn- and anti-tetrahydropyrimidine cores of manzacidins are reported. The …
sebastian-bretzke