Organic Synthesis

Efficient Synthesis of Chiral ProTides through Copper Catalysis featured image

Efficient Synthesis of Chiral ProTides through Copper Catalysis

A new study introduces a novel method for the stereoselective synthesis of chiral phosphates in ProTide nucleoside analogues.

Exploring Anti-Bredt Olefins as Reactive Intermediates featured image

Exploring Anti-Bredt Olefins as Reactive Intermediates

The access and the usage of anti-Bredt type olefins as intermediates are described in a new study in Science.

Synthesis of Quaternary Centres using Lithium Enolates in a Ru-catalysed Allylic substitution featured image

Synthesis of Quaternary Centres using Lithium Enolates in a Ru-catalysed Allylic substitution

The construction of quaternary centers via C-C bond formation is a significant challenge, but a new method reported in JACS, provides a promising approach to accessing these …