Deracemisation lead to enriched alpha Amino Aldehydes
Luo and coworkes from Tsinghua University report a novel method for deracemisation in JACS
Feb 12, 2025
Novel Synthetic Approach for the Synthesis of Pyrroloiminoquinones
The total synthesis of aleutianamin was enabled by a new convergent coupling reaction.
Feb 11, 2025
Computer aided Total Synthesis of 25 Picrotoxanes (Li, Shenvi)
Calculations optimise the total synthesis of natural products by addressing challenges in the 1,5 HAT key reaction.
Jan 24, 2025
Efficient Synthesis of Chiral ProTides through Copper Catalysis
A new study introduces a novel method for the stereoselective synthesis of chiral phosphates in ProTide nucleoside analogues.
Nov 13, 2024
Exploring Anti-Bredt Olefins as Reactive Intermediates
The access and the usage of anti-Bredt type olefins as intermediates are described in a new study in Science.
Nov 10, 2024
Macrocycles can lock the Conformation of Drug Candidates and enhance their Activity
Macrocycles can improve the conformation, biological activity, selectivity, ADME properties, and target affinity of small-molecule drug candidates.
Sep 10, 2024
Synthesis of Quaternary Centres using Lithium Enolates in a Ru-catalysed Allylic substitution
The construction of quaternary centers via C-C bond formation is a significant challenge, but a new method reported in JACS, provides a promising approach to accessing these sterically crowded motifs.
Aug 24, 2024
Synthesis of Drug Libraries using Sulfamide Linker Strategy
A coupling strategy ready for use in a 96 well plate.
Aug 21, 2024
Ring Closing Alkyne Metathesis allows unified Synthesis of Strasseriolides A to D
Synthesis of stasseriolide natural products and their analogues using a ring-closing alkyne metathesis by Alois Fürstner and his team.
Aug 10, 2024
Pfizer's Second-Generation SARS-CoV-2 Protease Inhibitor
Researchers from Pfizer have developed a structurally-optimized SARS-CoV-2 main protease inhibitor with improved metabolic stability compared to nirmatrelvir which is now in clinical trials.
Jul 27, 2024