Novel type warheads expand toolbox for covalent inhibitors
Synthetic access to strained bicyclobutane sulfonamides enabled the discovery of novel covalent warheads.
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New Targets for Molecular Glues
Human proteasome data mining study expands the possibilites of protein degradation.
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Selective Nitrosation by Covalent Binder Strategy
A novel strategy for improving our understanding of, and ability to utilise, nitrosation as a post-translational modification.
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New Method for Skeletal Rearrangement Enhances the Organic Chemist's Toolbox
Acyl transposition in dihydrobenzofuranes describend by Richmond Sarpong in Science
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Deracemisation lead to enriched alpha Amino Aldehydes
Luo and coworkes from Tsinghua University report a novel method for deracemisation in JACS
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Novel Synthetic Approach for the Synthesis of Pyrroloiminoquinones
The total synthesis of aleutianamin was enabled by a new convergent coupling reaction.
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Computer aided Total Synthesis of 25 Picrotoxanes (Li, Shenvi)
Calculations optimise the total synthesis of natural products by addressing challenges in the 1,5 HAT key reaction.
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Efficient Synthesis of Chiral ProTides through Copper Catalysis
A new study introduces a novel method for the stereoselective synthesis of chiral phosphates in ProTide nucleoside analogues.
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Exploring Anti-Bredt Olefins as Reactive Intermediates
The access and the usage of anti-Bredt type olefins as intermediates are described in a new study in Science.
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Macrocycles can lock the Conformation of Drug Candidates and enhance their Activity
Macrocycles can improve the conformation, biological activity, selectivity, ADME properties, and target affinity of small-molecule drug candidates.
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