A Real World Example: Using AI Tools for Drug Discovery
AstraZeneca’s recent HPK1 study demonstrates that generative AI can successfully discover novel, clinically viable chemical scaffolds, provided the algorithms are backed by …
Novel type warheads expand toolbox for covalent inhibitors
Synthetic access to strained bicyclobutane sulfonamides enabled the discovery of novel covalent warheads.
New Targets for Molecular Glues
Human proteasome data mining study expands the possibilites of protein degradation.
Selective Nitrosation by Covalent Binder Strategy
A novel strategy for improving our understanding of, and ability to utilise, nitrosation as a post-translational modification.
New Method for Skeletal Rearrangement Enhances the Organic Chemist's Toolbox
Acyl transposition in dihydrobenzofuranes describend by Richmond Sarpong in Science
Deracemisation lead to enriched alpha Amino Aldehydes
Luo and coworkes from Tsinghua University report a novel method for deracemisation in JACS
Novel Synthetic Approach for the Synthesis of Pyrroloiminoquinones
The total synthesis of aleutianamin was enabled by a new convergent coupling reaction.
Computer aided Total Synthesis of 25 Picrotoxanes (Li, Shenvi)
Calculations optimise the total synthesis of natural products by addressing challenges in the 1,5 HAT key reaction.
•
1 min read
Efficient Synthesis of Chiral ProTides through Copper Catalysis
A new study introduces a novel method for the stereoselective synthesis of chiral phosphates in ProTide nucleoside analogues.
•
1 min read
Exploring Anti-Bredt Olefins as Reactive Intermediates
The access and the usage of anti-Bredt type olefins as intermediates are described in a new study in Science.