The construction of quaternary centers via C-C bond formation is a significant challenge, but a new method reported in JACS, provides a promising approach to accessing these …
A coupling strategy ready for use in a 96 well plate.
Synthesis of stasseriolide natural products and their analogues using a ring-closing alkyne metathesis by Alois Fürstner and his team.
Researchers from Pfizer have developed a structurally-optimized SARS-CoV-2 main protease inhibitor with improved metabolic stability compared to nirmatrelvir which is now in …
Novel biocatalytic method for the diversification of thionucleosides, demonstrating that enzyme-catalyzed transglycosylation can effectively facilitate nucleobase exchange.
![Breaking the aromaticity of thiophene using a [4+3] cycloaddition featured image](/post/thiophene-angew-2024/featured_hu_950411bbaf1d50d7.webp)
A novel dearomative, intramolecular [4+3]-cycloaddition of thiophenes at low temperatures yielding complex tricyclic ring systems.
The development of a novel 4'-CN remdesivir-type nucleoside analogue demonstrating the potential of 4-aza-7,9-dideazaadenosine nucleoside analogues to exhibit antiviral activity.
Researchers modified the structure of the established antibiotic bacitracin, leading to a 256-fold increase in activity and potent inhibition of vancomycin-resistant strains.
Researchers from Shandong University in China reported the total synthesis of platensilin and platensimycin, as well as the formal synthesis of platencin in JACS, using a …
A radical cascade strategy to synthesize the complex marine natural product, Scabrolide A, is described in JACS by Pengfei Hu and coworkers.