Total Synthesis of Complex Natural Products
Total synthesis stands as one of the most intellectually demanding and logistically challenging disciplines within organic chemistry. Unlike highly applied branches such as process …
•
4 min read
Novel Synthetic Approach for the Synthesis of Pyrroloiminoquinones
The total synthesis of aleutianamin was enabled by a new convergent coupling reaction.
•
1 min read
Computer aided Total Synthesis of 25 Picrotoxanes (Li, Shenvi)
Calculations optimise the total synthesis of natural products by addressing challenges in the 1,5 HAT key reaction.
•
1 min read
Ring Closing Alkyne Metathesis allows unified Synthesis of Strasseriolides A to D
Synthesis of stasseriolide natural products and their analogues using a ring-closing alkyne metathesis by Alois Fürstner and his team.
•
1 min read
Novel Synthesis Route to Platensilin and Analogues
Researchers from Shandong University in China reported the total synthesis of platensilin and platensimycin, as well as the formal synthesis of platencin in JACS, using a …
•
1 min read
My Reading Tip of the Week: Total Synthesis of Scabrolide A by Radical Cascade
A radical cascade strategy to synthesize the complex marine natural product, Scabrolide A, is described in JACS by Pengfei Hu and coworkers.
•
1 min read
Modular total synthesis of iso-archazolids and archazologs
Full details on the design, development, and successful implementation of suitable synthetic strategies directed toward the total synthesis of iso-archazolids and archazologs are …
Synthesis of novel potent archazolids: Pharmacology of an emerging class of anticancer drugs
Vacuolar type ATPase (V-ATPase) has recently emerged as a promising novel anticancer target based on extensive in vitro and in vivo studies with archazolids, complex polyketide …
Total synthesis of archazolid F
A partial bioinspired as well as the total synthesis of archazolid F, a highly potent V-ATPase inhibitory, antiproliferative polyketide macrolide, is described. Key features of the …
Total syntheses of the archazolids: an emerging class of novel anticancer drugs
V-ATPase has recently emerged as a promising novel anticancer target based on extensive in vitro and in vivo studies with the archazolids, complex polyketide macrolides which …